Epictetus’ Handbook (the Enchidrion) is the quintessential ancient Stoic guide to a good life. This collection of quotes and aphorisms, compiled by one of Epictetus’ students, Arrian of Nicomedia, is still very much indispensable today. However, both science and philosophy have made some progress since the time of Epictetus, which is why in this lecture scientist, philosopher, and Stoic practitioner Massimo Pigliucci gives Epictetus — and by extension the whole of the Stoic philosophy — an update for the 21st century.